Threatened abortion treatment efficacy depending on progesterone receptor gene polymorphism

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[Progesterone receptor gene polymorphism and recurrent spontaneous abortion].

PURPOSE To assess a possible association between polymorphism of the progesterone receptor gene (PROGINS) and recurrent spontaneous abortion (RSA). METHODS In this case-control study, 85 women with at least three previous spontaneous abortions without an identifiable cause (RSA Group) and 157 women with at least two previous term pregnancies without pathologies and no previous miscarriage (Co...

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Effects of vaginal progesterone suppository on uterine artery resistance in women with threatened abortion

Introduction: Adequate levels of progesterone and efficient uteroplacental circulatory system are considered as two important factors in maintaining normal pregnancy. Conspicuously, increased vascular resistance in the uterine artery can lead to severe complications including threatened abortion by an impairment to the embryo’s blood supply. This study was conducted to determine whether vaginal...

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Frequency of Polymorphism Alu Insertion in Progesterone Receptor Gene in Endometriosis

Background and Aims: This research aimed to study a possible link between endometriosis and polymorphism of the progesterone receptor gene. Materials and Methods: The control group consisted of 86 women without endometriosis and the case group comprised 86 patients with a diagnosis of endometriosis by laparoscopy. Genotypes for Alu insertion polymorphisms (A1/A1, A1/A2 and A2/A2) were descri...

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Association of Alu Insertion Polymorphism in Progesterone Receptor Gene with Risk of Multiple Sclerosis

Background and purpose: Multiple sclerosis (MS) is a chronic autoimmune disease in which the myelin sheaths of nerve cells in the brain and spinal cord are damaged. The prevalence of disease is higher in women and it seems that sex hormones, which usually exert their effects through receptors, are involved in susceptibility to MS. Considering the functional role of Alu insertion 306 bp polymorp...

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The Effect of Progesterone Suppositories on Threatened Abortion: A Randomized Clinical Trial

BACKGROUND Threatened abortion is a common complication of pregnancy. In order to prevent miscarriage in the cases with threatened abortion, this study was conducted to determine whether progesterone suppository is effective in allowing pregnancy to proceed beyond week 20 in women with threatened abortion. METHODS This single-blind clinical trial study was done on 60 pregnant women with threa...

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ژورنال

عنوان ژورنال: Bukovinian Medical Herald

سال: 2017

ISSN: 2413-0737,1684-7903

DOI: 10.24061/2413-0737.xxi.1.81.2017.9